Research Studies

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Studies

• Active Brains: To assess how well their website works. ‘Active Brains’ aims to help older adults to look after their brain and body health. The aim is to help prevent problems with things like remembering, concentrating or reasoning (known as cognitive decline). The website will help older adults to make simple changes such as getting more active, playing brain training games and finding ways to eat more healthily.
• AMALFI:  Comparing a single two-week screening period for AF with the Zio system to usual care in individuals with no history of AF and elevated risk of stroke, based on the CHA2DS2-VASc score.
• ATHENA: To determine the clinical and cost effectiveness of prophylactic low-dose amitriptyline for the prevention of post-herpetic neuralgia (PHN) in patients diagnosed with herpes zoster (HZ). (Shingles)
• Baby Fuss: To interview parents and carers of infants (12 months of age or younger) to explore their understanding of symptoms and their feeding decisions and help-seeking behaviour. A better understanding of parents and carers’ experiences and actions will inform future research on how healthcare professionals can best help parents and carers look after infants while avoiding unnecessary or excessive use of medications.
• CatheterII: To determine whether the addition of a policy of prophylactic catheter washouts on a weekly basis to the current standard LTC care improves the outcome of cared for people living with LTC in the UK.
• CCP Next Gen: The aim is to determine the proportion of community patients with new-onset, non-specific musculoskeletal complaints who are anti-CCP antibody positive by identifying a cohort of individuals at high risk of developing inflammatory arthritis (IA), who may be appropriate for interventional research (including drug trials) aimed at preventing progression to IA.
• Com-CoV: The purpose of this study is to find out how well young people (aged 12-16 years) respond to two doses of COVID-19 vaccine. They want to find out if giving two doses of different vaccines produces as good an immune response as giving two doses of the same vaccine, in young people.
• CROCUS: Patients with urinary tract infection (UTI). The aim of this project is to evaluate the circumstances around a patient’s own behaviour and primary care management regarding UTI-derived E.coli septicaemia and to determine if there are variables that are significantly associated with this condition.
• DaRe2THINK: A study to evaluate whether oral anticoagulants can prevent stroke, premature death and cognitive decline in a broader community of patients with atrial fibrillation using healthcare data for pragmatic research: A randomised controlled trial
• DURATION: Study aiming to find the shortest length of time we can give someone an antibiotic when they have a urinary tract infection (UTI) and still be able to treat that infection effectively
• E.mbrace: The E.mbrace Study will assess the effectiveness and safety of an investigational vaccine versus a placebo – a vaccine that contains no active drug but which will look exactly like the investigational vaccine – in the prevention of a bloodstream infection in adults aged 60 or over who have had a urinary tract infection (UTI) in the past two years. The investigational vaccine or placebo will be given as a single injection.
• EMBRACE: Assess the Efficacy, Safety And Immunogenicity of Vaccination With ExPECMV in the Prevention of Invasive Extraintestinal Pathogenic Escherichia coli Disease (IED) in Adults Aged 60 Years And Older with a History of Urinary Tract Infection in the Past 2 Years.
• Gentle Years Yoga (GYY): Study looking into whether Yoga can help to improve health and wellbeing in patients over 65 with multimorbidities, defined as when a person has two or more long-term health conditions.
• Harmonie: Help further research on RSV infection (respiratory syncytial virus). If your baby is newborn to 12 months old, they may be eligible to participate in a study looking at how babies may be protected from serious illness due to RSV infection (respiratory syncytial virus). 
• HipDyS: Evaluation of aid to diagnosis for congenital dysplasia of the hip in general practice: controlled randomised trial
• LTC Scale: Eligible patients are asked to complete the scale and five additional validated questionnaires which will measure how the perceive their quality & satisfaction with life; what additional support, if any, they receive to help with daily life
• NewKI: Cardiovascular disease is a major cause of morbidity and death in CKD. This study looks at prevalence, incidence and progression of CKD in the UK and alternative renal biomarkers may have greater accuracy for cardiovascular risk stratification but their predictive role as assessed in prospective studies has not been established.
• OPTIMISE2: Looking at deprescribing antihypertensive medication in the over 75s.
• OxVALVE: Two aims: firstly, to identify people with Valvular Heart Disease and hence to establish its incidence within the population. Secondly, by further investigation we hope to develop improved treatment strategies for Valvular Heart Disease.
• PAM: A study evaluating a new text message/ smartphone app intervention aiming to support medication adherence to people prescribed treatment for hypertension
• PANORAMIC: PANORAMIC aims to determine the effectiveness of selected antiviral agents in preventing hospitalisation and/or death in higher-risk patients with a confirmed positive SARS-CoV-2 PCR test result.
• PATHOR: To evaluate the effectiveness of an online hub of newly developed resources which aim to improve knowledge of and de-stigmatise PMI (perinatal mental illness) for prospective/new parents, healthcare professionals and employers.
• PRINCIPLE: The PRINCIPLE trial aims to find treatments that reduce hospital admission and improve symptoms for people with COVID-19.
• PROMDEP: The study will look at whether giving personal feedback to people being treated for depression might help them get better more quickly. This will be done by using patient reported outcome measures ('PROMs') which involve patients completing questionnaires to record their symptoms of depression and feeding back these results to the practitioners looking after them.
• QUAL-HF: This study aims to find out what people think of a potential new pathway to identify patients with heart failure.
• RAPTOR: A research study to compare how accurate different tests are at detecting past or current coronavirus (COVID-19) infection.
• RCGP serology surveillance: To provide information on background population immunity to Covid-19. This is important in order to detect the number of infections within the population and to help inform public health surveillance and planning.
• SAFER-AF: A programme of research investigating screening to detect atrial fibrillation, a heart condition responsible for one in ten strokes
• STATIC: To compare the safety and effectiveness of continuing existing 5-ASA medication versus stopping it in patients with Chron’s disease in remission
• STREAM: Nutrition in older patients.
• SuMMiT-D: Support through mobile messaging & digital health technology for diabetes
• TAILOR: An observational study on preschool wheeze to help predict future wheezing exacerbations and guide treatment more efficiently
• Treat to target T2T Gout: A study to determine the clinical and cost-effectiveness of treat-to-target urate lowering therapy in people with recurrent gout flares compared to usual care
• TOUCAN: The TOUCAN study is testing new devices that, hopefully, will quickly tell a GP whether a patient
  has a urinary tract infection.
• VASP: Development of a Live Attenuated Vaccine against Salmonella Paratyphi A. VASP aims to find out if a weakened form of Salmonella Paratyphi A bacteria can act as a vaccine to protect individuals without causing disease.
• Virus Watch: To work out why Covid-19 is affecting some communities more than others by learning from people in every community in the UK. We will be looking into access, and effectiveness of, Covid-19 vaccines.